I thus don’t choose one relationships between CO pricing and you may structure specificity

I thus don’t choose one relationships between CO pricing and you may structure specificity

Sex devotion family genes have a beneficial recombinational wilderness

Given the correlation noted above between high gene density and low crossing-over rates, perhaps the association with worker brains simply reflects their residing in domains of low density? The gene density across the whole genome is 4.1 genes/100 kb. Surprisingly, then worker-brain-biased genes reside in regions of higher gene density, averaging 9.0 genes/100 kb, and so, all else being equal, should have low crossing-over rates. Indeed, when compared with other genes from domains of similar gene density, worker-brain bias genes are very highly enriched near COs (chi sq-test, P <2.2e-16: for worker-brain-bias genes vs. for genes in similar gene density). The correspondence with high gene density is not simply a consequence of tandem gene duplication favoring worker-brain-biased genes. Of 752 worker genes 701 are single copy genes (query and hit with overlapping region >50% and identity >50% are treated as paralogs). These singletons are closer (<10 kb) to recombination hotspots than expected by chance (P <1e-9 in chi square-test, method as in Table S8) and in domains of high density (9 genes/100 kb). These results provide prima facie support for the hypothesis that selection favors the higher recombination rate in worker brain genes.

Comparable overall performance was and observed in places having duplicate matter differences, in a fashion that the brand new genes with employee-brain biased term compared to queen’s otherwise drone’s mind is actually strongly on the backup matter variations (Dining table S8B and you will S8C inside Even more document 2). Continue reading “I thus don’t choose one relationships between CO pricing and you may structure specificity”